AML/ETO融合基因检测试剂盒 荧光原位杂交法

AML/ETO融合基因检测试剂盒 荧光原位杂交法

广州健仑生物科技有限公司

我司还有很多荧光原位杂交系列检测试剂盒以及各种FISH基因探针和染色体探针等，。

    t（8；21）（q22；q22）是初治急性粒细胞白血病（AML）患者中常见的细胞遗传学异常，大约20%～40%的AML-M2患者有t（8；21）（q22；q22），并且在M2b亚型中发生率高达90%以上。位于染色体21q22的AML1基因与8q22的ETO基因融合，产生AML1/ETO融合基因。AML1/ETO融合基因是转录激活基因，导致细胞不断增殖。临床上t（8；21）白血病好发于青年和儿童（5%～10%），主要与M2型密切相关，并且年龄越小发生率越高。t（8；21）代表预后较好的急性白血病类型，成人患者对治疗反应佳，*缓解率高，中位生存时间长，但易复发；儿童患者的治疗和预后不如成人患者理想。AML1/ETO融合基因可作为M2b诊断分型的标志，以及微小残留病灶监测的一项检测手段。

AML/ETO融合基因检测试剂盒 荧光原位杂交法

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以下是我司出售的部分FISH产品：

Over the past decades, researchers have found over 100 genes that may increase the risk of schizophrenia, which can lead to a serious mental disorder, which can lead to chaotic thinking, delusion and hallucination. One of these genes is called neuromodulation protein 3, which has a higher risk of schizophrenia. But until recently, researchers have not been able to determine how neuromodulation protein 3 affects the risk of schizophrenia.
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A new study has shown how a highly risky gene inhibits key brain chemicals.
In February 20, 2018 "published in the proceedings of the National Academy of Sciences" (Proceedings of the National Academy of Sciences) a new study in the journal, Cleveland (Cleveland) Western Reserve University (Case Western Reserve University) researchers found that neuregulin 3 and some neurotransmitters (chemical substances to help brain cells to communicate with each other the occurrence of chaos). They said that these findings may help to further develop a more targeted drug therapy for schizophrenia and other severe mental disorders in the future.
In the United States, 1 of the 100 people have schizophrenia, and the cause of schizophrenia is not yet clear. Doctors and scientists believe that the combination of genes and environmental factors is likely to play a role.
Dr. neuroscientist Lin Mei Ohio at Cleveland University School of medicine, said: "the treatment of severe mental illness is far from satisfactory. The brain is so complex that we have just begun to understand how different brain circuits and pathways interact to cause disease. "
This new study helps to reveal a potential pathway for the nerve to be affected: the neuroregulated protein 3 (also known as neuregulin 3). Dr. Mei and his colleagues know that some people with schizophrenia have increased the level of protein, but it is not clear what the level of this protein is related to the risk of schizophrenia.
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What is the link between genetics (gene) and mental illness?
Dr. Mei and his colleagues mutated the genes encoding the neuroregulatory protein 3 protein in different brain cell groups in mice. They want to prove which types of brain cells may be sensitive to changes in protein levels. When they are in pyramidal neurons (a special type of help to activate the brain's brain cells) in the mutant gene, they found that mice are difficult to navigate in the maze, and unfamiliar mice exhibiting strange behavior, researchers say these behaviors and schizophrenia is consistent.
Dr. Mei said schizophrenia is a mental disorder, and it is impossible to know what the mice are thinking. Mouse studies can help researchers identify the types of nerve cells that may be involved.
There is evidence that genes may interfere with the communication of brain cells.
The researchers then carefully studied the role of neuromodulation protein 3 at the cellular level. They cultured pyramidal neurons in Petri dishes of laboratory, and increased the level of neural regulatory protein 3 to simulate the protein levels found in the brains of schizophrenic patients.